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Article
February 1987

Infiltrated Blue-Gray Plaques in a Patient With Leukemia

Author Affiliations

University of Texas Medical School (Drs Cohen and Rapini), M. D. Anderson Cancer & Tumor Institute (Dr Beran), Houston

Arch Dermatol. 1987;123(2):251-252. doi:10.1001/archderm.1987.01660260121027
Abstract

REPORT OF A CASE  A 52-year-old woman presented with extensive asymptomatic blue-gray infiltrated plaques on her face (Figs 1 and 2) and multiple purple nodules on her chest (Fig 3). She had been diagnosed seven months earlier as having Philadelphia chromosome-negative chronic myelomonocytic leukemia, which had transformed into acute myelomonocytic leukemia (AMML). She achieved complete remission after treatment with 4′-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA), vincristine, cytosine arabinoside, and prednisone. The skin lesions appeared within a month after her first course of maintenance chemotherapy. She had not been taking any other medications and had experienced no significant exposure to mercury, silver, bismuth, or gold.Results of laboratory tests revealed the following values: hemoglobin, 9.8 g/dL (98 g/L); hematocrit, 26.8% (0.27); mean corpuscular (MC) volume, 97 μm3 (97 fL); MC hemoglobin, 35.6 pg; MC hemoglobin concentration, 36.6 g/dL (366 g/L); white blood cell count, 12100/mm3 (12.1 × 109/L); differential cell count,

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