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April 1987

Familial Occurrence of Lichen Sclerosus et AtrophicusCase Reports of a Mother and Daughter

Author Affiliations

From the Department of Dermatology, Ochsner Clinic and Alton Ochsner Medical Foundation (Drs Shirer and Ray), and the Department of Dermatology, Louisiana State University (Dr Shirer), New Orleans.

Arch Dermatol. 1987;123(4):485-488. doi:10.1001/archderm.1987.01660280087030

• A mother and daughter with lichen sclerosus et atrophicus (LSA) are described. Both had lesions restricted to their lower legs. Both patients were positive for HLA-B40, which has been associated with LSA. Sex steroid hormones showed no decrease in dihydrotestosterone, free testosterone, or androstenedione levels in the daughter as was demonstrated in a previous study of this disease, but did show some decrease in androstenedione in the mother. This article provides further evidence for a possible familial predisposition for LSA.

(Arch Dermatol 1987;123:485-488)