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April 1987

The CHILD SyndromeHistologic and Ultrastructural Studies

Author Affiliations

From the Departments of Pediatrics and Dermatology, Northwestern University Medical School and Children's Memorial Hospital, Chicago (Drs Hebert and Esterly); the Departments of Biological Structure and Medicine (Dermatology), University of Washington School of Medicine, Seattle (Dr Holbrook); and St Luke's Hospital, Kansas City, Mo (Dr Hall). Dr Hebert is now with the Departments of Dermatology and Pediatrics, University of Texas Medical School, Houston.

Arch Dermatol. 1987;123(4):503-509. doi:10.1001/archderm.1987.01660280105034

• A 4½-month-old female infant had cutaneous and musculoskeletal changes consistent with the diagnosis of congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome. This syndrome encompasses abnormalities of several organ systems, and its origins and pathogenesis are poorly understood. This report describes an additional patient with this uncommon syndrome and includes light and electron microscopic studies of her skin lesions. Our patient's clinical features of meningocele, Shone's syndrome, and the electron microscopic findings have not previously been described in the American literature (to our knowledge) in association with this syndrome.

(Arch Dermatol 1987;123:503-509)