• Eighteen patients developed Staphylococcus aureus infection during or shortly after a five-month course of therapy with isotretinoin. Staphylococcus aureus was recovered both from lesions and from the anterior nares. In a prospective study, 4% of control patients treated with isotretinoin alone developed S aureus infection, while none who applied topical antibiotic to the anterior nares developed infection. Control patients had a 64% prevalence of anterior nares colonization with S aureus, compared with 18% in the topical antibiotic group.
(Arch Dermatol 1987;123:606-608)
Leyden JJ, James WD. Staphylococcus aureus Infection as a Complication of Isotretinoin Therapy. Arch Dermatol. 1987;123(5):606-608. doi:10.1001/archderm.1987.01660290074019