To the Editor.—
The ectodermal dysplasias form a heterogeneous group of conditions that are poorly understood both clinically and causally.1 We describe a new type of ectodermal dysplasia characterized by onychodysplasia and trichodysplasia that affected seven individuals spanning three generations. We attempted to find a hair protein alteration in this family that could aid in diagnosis and counseling. Hair samples were obtained from the unaffected mother and daughter and from the affected father and daughter in the first generation. These hairs were solubilized and hair proteins analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. A low-molecular-weight protein was found in the insoluble hair fractions obtained from the affected father and daughter, but not in those obtained from the normal family members or from a control group of normal individuals. The results of this family study suggest that hair proteins may be altered in the ectodermal dysplasias in which trichodysplasia is a prominent feature.
Hordinsky M, Berry S, Sundby S, Tsai MY, Townsend D, Panter S. Hair Protein Patterns in a New Autosomal Dominant Ectodermal Dysplasia. Arch Dermatol. 1987;123(6):716-718. doi:10.1001/archderm.1987.01660300032009