[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.179.146. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 1987

Recombinant Interferon Alfa-2b in Plaque-Phase Mycosis FungoidesIntralesional and Low-Dose Intramuscular Therapy

Author Affiliations

From the Department of Dermatology, Temple University Health Sciences Center, Philadelphia (Drs Vonderheid, Thompson, and Lattanand), and the Schering Corp, Kenilworth, NJ (Dr Smiles).

Arch Dermatol. 1987;123(6):757-763. doi:10.1001/archderm.1987.01660300079016
Abstract

• A two-part clinical trial was conducted to determine the therapeutic efficacy of recombinant interferon alfa-2b in plaque-phase mycosis fungoides. In an initial randomized double-blind study, each of six patients had two representative plaques injected intralesionally with 1 × 106 U of recombinant interferon alfa-2b per site and two control plaques injected with placebo three times weekly for four consecutive weeks. Complete clinical regression of disease was observed at ten of 12 recombinant interferon alfa-2b sites compared with one of 12 placebo-treated sites four weeks after treatment with injections was stopped. Subsequently, in an open-labeled study, five of these patients were treated intramuscularly with 5 × 106 U of recombinant interferon alfa-2b three times weekly for four weeks and two patients were treated with a second, more extended course of therapy lasting 12 to 16 weeks. Three of the five patients treated systemically showed some improvement overall, but the responses were judged not to be clinically significant. The differential response observed from intralesional and intramuscular injections may be related to differences in concentration of recombinant interferon alfa-2b achieved in lesional skin by the two methods of administration.

(Arch Dermatol 1987;123:757-763)

×