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August 1987

Mycosis Fungoides Treated With High-Dose Carmustine

Author Affiliations

177 Burt Rd Lexington, KY 40503 James L. O'Quinn, MD Department of Pathology Medical College of Georgia Augusta, Ga

Arch Dermatol. 1987;123(8):990. doi:10.1001/archderm.1987.01660320030004

To the Editor.—  We report a case of mycosis fungoides that cleared with carmustine treatment administered in an unconventional fashion.

Report of a Case.—  A 72-year-old woman was seen in our office with a four-month history of generalized involvement of the skin with erythematous, scaly infiltrated plaques on her scalp, extremities, trunk, and palms. There was no adenopathy. The lesions were pruritic and recalcitrant to topical and oral corticosteroids. A biopsy specimen obtained in October 1986 showed chronic, perivascular dermatitis with eosinophilia and epidermal spongiosis. Her antihypertensive medication was discontinued to eliminate the possibility of a drug hypersensitivity. However, she continued to have severe pruritus. There were no poikilodermatous changes to suggest parapsoriasis. Another biopsy specimen was obtained one month later to rule out mycosis fungoides. Analysis of the biopsy specimen showed an atypical lymphohistiocytic infiltrate with Pautrier's microabscesses.The patient lived in the mountainous area of Kentucky 120 miles

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