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Article
August 1987

Atypical Fibroxanthoma in a Patient With Xeroderma Pigmentosum

Author Affiliations

From the Departments of Pathology (Dr Patterson) and Dermatology (Drs Patterson and Jordan), Medical College of Virginia, Virginia Commonwealth University, Richmond.

Arch Dermatol. 1987;123(8):1066-1070. doi:10.1001/archderm.1987.01660320108023
Abstract

• A 3-year-old boy with xeroderma pigmentosum developed a papule on the right ala nasi that had the light-microscopic, immunohistochemical, and ultrastructural features of atypical fibroxanthoma. This lesion most commonly arises on the sun-exposed skin of older adults. The occurrence of an atypical fibroxanthoma in such a patient adds weight to the concept that this tumor of "fibrohistiocytic" origin is induced by ultraviolet exposure. Mechanisms of tumor formation in a patient with xeroderma pigmentosum may be similar to those occurring in the more typical situation in adults.

(Arch Dermatol 1987;123:1066-1070)

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