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September 1987

T-Cell Receptor Gene Rearrangement in Regressing Atypical Histiocytosis

Author Affiliations

From the Departments of Pathology (Drs Headington and Schnitzer), Medicine (Drs Roth and Ginsburg), and Radiation Therapy (Dr Lichter), University of Michigan Medical School, Ann Arbor; and the Department of Pathology, Good Samaritan Hospital Medical Center, Portland, Ore (Dr Hyder). Dr Ginsburg is a Howard Hughes Medical Institute investigator.

Arch Dermatol. 1987;123(9):1183-1187. doi:10.1001/archderm.1987.01660330094017

† A case of regressing atypical histiocytosis having characteristic clinical and light microscopic findings was studied immunologically for immunoglobulin and T-cell receptor gene rearrangement and for DNA ploidy analysis. Immunologic phenotyping and rearrangement of T-cell receptor β- and γ-chain genes indicated that this primary cutaneous neoplasm, previously considered "histiocytic" in origin, is most probably of T-cell lineage.

(Arch Dermatol 1987;123:1183-1187)