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September 1987

Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency SyndromeImmunohistologic Evaluation of the Cellular Infiltrate

Author Affiliations

From the Departments of Dermatology (Drs Huerter and Bergfeld) and Pathology (Drs Bass, Bergfeld, and Tubbs), Cleveland Clinic Foundation.

Arch Dermatol. 1987;123(9):1217-1220. doi:10.1001/archderm.1987.01660330128025

• The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate—Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare.

(Arch Dermatol 1987;123:1217-1220)