• The drug, 13-cis-retinoic acid, which has been demonstrated to have a marked effect on nodulocystic acne, probably has several mechanisms of action. This article summarizes the effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy. These changes in lipid composition support the concept that linoleate may be of importance in the pathogenesis of acne.
(Arch Dermatol 1987;123:1538a-1541)
Strauss JS, Stewart ME, Downing DT. The Effect of 13-cis-Retinoic Acid on Sebaceous Glands. Arch Dermatol. 1987;123(11):1538a-1541. doi:10.1001/archderm.1987.01660350142031