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Article
January 1988

The Relationship Between Anti-Ro (SS-A) Antibody-Positive Sjögren's Syndrome and Anti-Ro (SS-A) Antibody-Positive Lupus Erythematosus

Author Affiliations

From the Department of Dermatology (Dr Provost) and Division of Rheumatology (Dr Alexander), Johns Hopkins Medical Institutions, Baltimore; Division of Clinical Immunology, University of Texas Health Science Center at San Antonio (Dr Talal); Department of Medicine (Dr Harley) and Immunology Section (Dr Reichlin), University of Oklahoma College of Medicine, Oklahoma City; Arthritis and Immunology Program, Oklahoma Medical Research Foundation, (Dr Provost); Veterans Administration Medical Center, Oklahoma City (Dr Harley); and Arthritis and Immunology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City (Dr Harley).

Arch Dermatol. 1988;124(1):63-71. doi:10.1001/archderm.1988.01670010027017
Abstract

• Ten Ro(SS-A) antibody-positive patients with Sjögren's syndrome and lupus erythematosus are described. These patients have a disease process characterized by the frequent appearance of annular polycyclic lupus lesions of subacute cutaneous lupus erythematosus (SCLE), as well as neurologic and pulmonary disease. The Ro(SS-A) antibody-positive patients may have Sjögren's syndrome for many years and then suddenly develop lupus erythematosus, and vice versa. These studies demonstrate that the patient with Ro(SS-A) antibody may exhibit a dynamic clinical disease expression over time and that there is a closer pathologic relationship between Sjögren's syndrome and SCLE in these patients with Ro(SS-A)-antibody than has previously been appreciated. Furthermore, Ro(SS-A)-positive patients with Sjögren's syndrome and lupus erythematosus appear to have a much more guarded prognosis than those Ro(SS-A)-positive lupus patients described under the classifications of antinuclear antibody-negative lupus erythematosus and SCLE.

(Arch Dermatol 1988;124:63-71)

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