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February 1988

Potential Roles of Fibronectin in Cutaneous Wound Repair

Author Affiliations

From the Dermatology Program, National Jewish Center for Immunology and Respiratory Medicine, Denver.

Arch Dermatol. 1988;124(2):201-206. doi:10.1001/archderm.1988.01670020019010

• Fibronectin has many potential roles in wound repair, including chemotactic factor activity for monocytes, fibroblasts, and endothelial cells; opsonin activity and opsonin promoter activity for microorganism and tissue debris; substratum for cell migration and localization; and a scaffold for building extracellular matrix. Although fibronectin has been reported to have intrinsic growth-promoting ability, coisolation of authentic growth factors with fibronectin raises doubts about this observation. Whether the addition of exogenous fibronectin to wounds can augment healing is a question for future studies.

(Arch Dermatol 1988;124:201-206)