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March 1988

Topical Minoxidil Therapy for Androgenetic Alopecia-Reply

Arch Dermatol. 1988;124(3):322-323. doi:10.1001/archderm.1988.01670030010006

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In Reply.—  We thank Dr Ernst Epstein for his comments. While we share his obvious concern for the best interests of balding patients, we felt that it was essential to make our outcome measurements as quantitative and objective as possible.While improvement in appearance and cosmeticimprovement are laudable therapeutic goals, we find these terms to be nebulous and impossible to quantify. Over the years of our study, we were particularly impressed by the range of responses that were cosmetically acceptable to our patients. Some patients were disappointed with anything less than a full head of hair, while most were pleased to have achieved any amount of hair regrowth. Some patients were content to simply maintain their amount of hair by slowing down or arresting the amount of active hair loss.As clinical investigators, we are obliged to make our best efforts to observe and measure responses as objectively as possible. Hair

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