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Dr Nathanson has provided us with a meaty and highly informative monograph on the treatment of advanced melanoma. Attempts to treat the metastatic phase of this "fascinating and frustrating disease" have produced a wide range of research strategies, and this monograph addresses those strategies in a comprehensive and clear manner. The book begins with a review of traditional chemotherapeutic agents, moves on to comment on the role of retinoids and autologous bone marrow transplantation, and finally puts into perspective other treatment modalities, such as monoclonal antibodies, subrenal capsule assay, hyperthermia, interferons, antipigmentary agents, and steroid hormones. The chapters are succinct, well organized, and enhanced by many tables that summarize a great deal of material in concise fashion. For treatment options for which little data exist, the authors often conjecture about possible future research directions— hence, the monograph offers an interesting mix of present knowledge and hypotheses worthy of future testing.
Koh HK. Management of Advanced Melanoma: VI. Contemporary Issues in Clinical Oncology. Arch Dermatol. 1988;124(4):601. doi:10.1001/archderm.1988.01670040083032