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May 1988

Cutaneous Angiomas in POEMS SyndromeAn Ultrastructural and Immunohistochemical Study

Author Affiliations

From the Department of Dermatology, Hôpital Edouard Herriot, Lyon (Drs Kanitakis and Chouvet); the Department of Dermatology, Hôpital Hôtel Dieu (Drs Roger and Souteyrand); and the Rheumatology Section, Department of Clinical Immunology, Hôpital Saint Jacques (Drs Dubost and Soubrier), Clermont-Ferrand, France.

Arch Dermatol. 1988;124(5):695-698. doi:10.1001/archderm.1988.01670050039016

• Cutaneous manifestations of POEMS (polyneuropathy, organomegaly, endocrinopathies, M-protein, and skin changes) syndrome in a 51-year-old white man included two types of hemangiomas, ie, cherry-type and subcutaneous hemangiomas. By light microscopy and immunohistochemistry, both types of tumors showed features of capillary hemangiomas. By electron microscopy, a peculiar finding of subcutaneous hemangiomas was the presence of slender abluminal processes of endothelial cells that were frequently anastomosing to form electron-lucent blebs. Although the precise etiopathogenesis of the vascular proliferations remains speculative, these lesions merit study since they constitute an easily recognizable marker of POEMS syndrome.

(Arch Dermatol 1988;124:695-698)