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May 1988

Antigenic Features and Structural Correlates of Basement MembranesRelationship to Epidermolysis Bullosa

Author Affiliations

From the Department of Dermatology, University of Alabama in Birmingham School of Medicine, and the Dermatology Section, Birmingham (Ala) Veterans Administration Medical Center.

Arch Dermatol. 1988;124(5):713-717. doi:10.1001/archderm.1988.01670050057022

• Numerous antigenic epitopes are present within the dermoepidermal junction of human skin. Using monoclonal antibodies, the distribution of these epitopes in ontogeny, wound healing, and epidermolysis bullosa are being defined. These studies provide insight into the pathogenic mechanisms involved and offer opportunities for prenatal and postnatal diagnosis.

(Arch Dermatol 1988;124:713-717)