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May 1988

A Perspective on the Role of Collagenase in Recessive Dystrophic Epidermolysis Bullosa

Author Affiliations

From the Division of Dermatology, Department of Medicine, and the Washington/Dystrophic Epidermolysis Bullosa Research Association Center for Research and Therapy of Epidermolysis Bullosa, Washington University School of Medicine, St Louis.

Arch Dermatol. 1988;124(5):734-736. doi:10.1001/archderm.1988.01670050078026

• The pathophysiology of tissue fragility in recessive dystrophic epidermolysis bullosa may be due in part to excessive destruction of interstitial collagens by a structurally altered, but catalytically active, form of human skin collagenase. Therapeutic attempts directed toward reducing the expression of this enzyme have resulted in clinical improvement in some patients with the disease.

(Arch Dermatol 1988;124:734-736)