• The pathophysiology of tissue fragility in recessive dystrophic epidermolysis bullosa may be due in part to excessive destruction of interstitial collagens by a structurally altered, but catalytically active, form of human skin collagenase. Therapeutic attempts directed toward reducing the expression of this enzyme have resulted in clinical improvement in some patients with the disease.
(Arch Dermatol 1988;124:734-736)
Bauer EA, Tabas M. A Perspective on the Role of Collagenase in Recessive Dystrophic Epidermolysis Bullosa. Arch Dermatol. 1988;124(5):734-736. doi:10.1001/archderm.1988.01670050078026