• Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.
(Arch Dermatol 1988;124:737-741)
Goldberg GI, Eisen AZ, Bauer EA. Tissue Stress and Tumor PromotionPossible Relevance to Epidermolysis Bullosa. Arch Dermatol. 1988;124(5):737-741. doi:10.1001/archderm.1988.01670050081027