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Article
May 1988

Current Problems in Dermatology: Biology of Heritable Skin Diseases

Author Affiliations

Chicago

 

edited by K. D. Wuepper and T. Gedde-Dahl, Jr, 254 pp, 62 illus and 26 tables, $162.75, New York, S Karger AG, 1987.

Arch Dermatol. 1988;124(5):788. doi:10.1001/archderm.1988.01670050120041

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Abstract

Like its predecessor, this volume of Current Problems in Dermatology also contains some articles read before two symposia in 1986. This volume is divided into the following five sections: genetic principles, the epidermis, the junction zone and dermis, DNA repair, and animal models. Some articles within each section are extremely interesting and well-prepared, while others appear to be somewhat controversial.

In the first section, Dr Sybert's chapter is an excellent introduction to genetic principles applied to the skin. She rightly stresses the issue of phenotypic (or genetic) heterogeneity as the most important genetic principle for clinical morphologists to understand. Dr Happle's chapter on Blashko's lines appears not to pay adequate attention to this important principle. However, it is a stimulating, if controversial, chapter that must be read. I found the chapter on gene expression during formation of the cuticle of Caenorhabditis eligans (a soil nematode) to be out of synchrony

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