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July 1988

Unusual Varicella Zoster Virus Infection in Patients With the Acquired Immunodeficiency Syndrome

Author Affiliations

First Clinic of Dermatology; Clinic of Infectious Diseases University of Milan Via Pace 9 20122 Milan, Italy

Arch Dermatol. 1988;124(7):1011-1013. doi:10.1001/archderm.1988.01670070013006

To the Editor.—  In patients with the acquired immunodeficiency syndrome (AIDS)- or human immunodeficiency virus (HIV)-related disorders, mucocutaneous manifestations caused by herpesvirus are frequent,1 and may present with unusual clinical features.2 Chronic anogenital ulcers due to herpes simplex virus (HSV), severe dermatomal herpes zoster (HZ), and protracted forms of varicella and vesiculobullous eruptions due to cytomegalovirus have all been described.3-5 The purpose of this article is to illustrate a peculiar form of disseminated ecthymatous varicella zoster virus (VZV) infection in two patients with AIDS, which was characterized by necrotic cutaneous lesions and a prolonged course.

Report of Cases.—Case 1.  —A 35-year-old bisexual man with a history of varicella during childhood and condylomata acuminata for one year was found to be seropositive to HIV in May 1986, when he was hospitalized for Pneumocystis carinii pneumonia and oral candidiasis. He developed cerebral toxoplasmosis in June 1986, and noted

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