• Glucose tolerance, lymphocyte populations, and HLA types were studied in 27 patients with untreated hidradenitis suppurativa; 18 of these patients had a negative history for acne vulgaris. Six patients (22%) had an increased incidence of impaired glucose tolerance. We failed to confirm a previous report of high incidence of flat glucose tolerance curves. The frequency of HLA-A and HLA-B antigen loci and the median values of peripheral blood T lymphocytes were similar to the control population. However, seven patients with moderate or severe clinical disease had a marked reduction in T lymphocytes and these patients had an increased frequency of the HLA antigens, A1 and B8. These results suggest that T lymphocytes may play a role in the pathogenesis of hidradenitis suppurativa and that HLA-A1 and HLA-B8 may predispose the patient to more severe disease, but further research is necessary to clarify this.
(Arch Dermatol 1988;124:1043-1046)
O'Loughlin S, Woods R, Kirke PN, Shanahan F, Byrne A, Drury MI. Hidradenitis SuppurativaGlucose Tolerance, Clinical, Microbiologic, and Immunologic Features and HLA Frequencies in 27 Patients. Arch Dermatol. 1988;124(7):1043-1046. doi:10.1001/archderm.1988.01670070031014