[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.147.196.37. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 1988

Sinus Histiocytosis With Massive LymphadenopathyCurrent Status and Future Directions

Author Affiliations

From the Department of Pathology, Presbyterian Hospital, and the Departments of Pathology and Dermatology, University of New Mexico School of Medicine, Albuquerque (Dr Foucar), the Department of Pathology, Yale University School of Medicine, New Haven, Conn (Dr Rosai), and the Department of Pathology, Stanford (Calif) University Medical School (Dr Dorfman).

Arch Dermatol. 1988;124(8):1211-1214. doi:10.1001/archderm.1988.01670080023011
Abstract

In the present issue of the Archives, Suster et al1 describe a 72-year-old woman with large soft-tissue masses that spontaneously disappeared over a period of several weeks. In spite of the absence of lymphadenopathy, the authors cautiously suggest the diagnosis sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai-Dorfman disease), based primarily on the biopsy finding of a certain cytologic subtype of S100-positive histiocytes exhibiting lymphocytophagocytosis. It is appropriate to ask just how reliable these morphological and immunologic features are in segregating a specific disease entity. If the findings are reliable, what is our current understanding of the clinical and pathologic features of this disease, how is it related to other "histiocytoses," and what are the major directions for investigation of this disease?

Histopathologic observations are currently used to subclassify many disease processes that are associated with proliferation of lymphoid and histiocytic cell lines, although immunophenotypic and immunogenotypic studies

First Page Preview View Large
First page PDF preview
First page PDF preview
×