To the Editor.—
Localized epidermolysis bullosa (EB) simplex (Weber-Cockayne disease) is an autosomal dominant bullous disease with a high penetrance that usually begins in infancy or early childhood. Blisters occur mainly on the hands and feet, often develop with warm ambient temperatures, and heal without scarring. We describe a woman with localized EB simplex treated successfully with isotretinoin.
Report of a Case.—
A 53-year-old woman with a lifelong history of localized EB simplex presented to the Department of Dermatology, Cleveland Clinic Foundation, for treatment in July 1987. Her blisters occurred primarily on the feet and, occasionally, on the palms and fingers, worsened during warm weather, resolved without scarring, and usually numbered 20 to 30 at any one time. She had accompanying tenderness and recurrent infections, primarily on the soles, due to the blistering. She had received no prior therapy.The patient's mother, two of her siblings, and two of her
Andreano JM, Tomecki KJ. Epidermolysis Bullosa Simplex Responding to Isotretinoin. Arch Dermatol. 1988;124(9):1445-1446. doi:10.1001/archderm.1988.01670090087027