• We describe a patient with long-standing severe leukocytoclastic vasculitis of the skin and essential mixed cryoglobulinemia type II, who showed a limited reaction to immunosuppressive drugs, plasmapheresis, and colchicine. Therapy with high-dose γ-globulin intravenously (IV) for five days resulted in disappearance of vasculitis lesions within three weeks. After γ-globulin IV treatment there was a decrease in cryoglobulin, circulating immune complexes, and IgMκ paraprotein, and a rise in complement levels. No serious side effects were noted during or after γ-globulin IV treatment. The patient has been in remission for 16 months.
(Arch Dermatol 1988;124:1550-1553)
Boom BW, Brand A, Bavinck JB, Eernisse JG, Daha MR, Vermeer B. Severe Leukocytoclastic Vasculitis of the Skin in a Patient With Essential Mixed Cryoglobulinemia Treated With High-Dose ?-Globulin Intravenously. Arch Dermatol. 1988;124(10):1550-1553. doi:10.1001/archderm.1988.01670100052013