• In patients with bullous hemorrhagic amyloidosis of the skin, the skin lesions were the first manifestations of a plasma cell dyscrasia. Both cases were characterized by similar clinical, histologic, and ultrastructural findings showing an intradermal blister within deposits of amyloid substances. Immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-A X serum in both patients.
(Arch Dermatol 1988;124:1683-1686)
Bieber T, Ruzicka T, Linke RP, von Kries R, Goerz G, Braun-Falco O. Hemorrhagic Bullous AmyloidosisA Histologic, Immunocytochemical, and Ultrastructural Study of Two Patients. Arch Dermatol. 1988;124(11):1683-1686. doi:10.1001/archderm.1988.01670110043009