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November 1988

Hemorrhagic Bullous AmyloidosisA Histologic, Immunocytochemical, and Ultrastructural Study of Two Patients

Author Affiliations

From the Departments of Dermatology (Drs Bieber, Ruzicka, and Braun-Falco) and Immunology (Dr Linke), Ludwig-Maximilians University, Munich; and the Department of Dermatology, University of Düsseldorf (Drs von Kries and Goerz), West Germany.

Arch Dermatol. 1988;124(11):1683-1686. doi:10.1001/archderm.1988.01670110043009

• In patients with bullous hemorrhagic amyloidosis of the skin, the skin lesions were the first manifestations of a plasma cell dyscrasia. Both cases were characterized by similar clinical, histologic, and ultrastructural findings showing an intradermal blister within deposits of amyloid substances. Immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-A X serum in both patients.

(Arch Dermatol 1988;124:1683-1686)