REPORT OF A CASE
A 62-year-old woman was well until eight weeks prior to evaluation when she develped, over a 24-hour period, painless edema of the lower lip without any provoking incident (Fig 1). The edema was more pronounced in the morning, with partial resolution later in the day. No palliation was achieved by warm or cold compresses, courses of several antihistamines, or a seven-day course of erythromycin therapy. There was no history of applied irritants, sensitizers, trauma, prolonged light exposure, photosensitivity, or facial paralysis.Physical examination revealed swelling of the lower lip with moderate fissuring of her tongue and resolving angular cheilitis. There was no regional lymphadenopathy.A biopsy specimen was obtained from the lower lip (Fig 2).What is your diagnosis?
A punch biopsy of the lip revealed spongiosis of the partially keratinized squamous mucosa. There was a patchy
Venable CE, Gaudio SA. Persistent Swelling of the Lower Lip. Arch Dermatol. 1988;124(11):1707-1708. doi:10.1001/archderm.1988.01670110067015