• We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.
(Arch Dermatol 1988;124:1831-1834)
Venencie PY, Boffa GA, Delmas PD, Verola O, Benkaïdali I, Frija J, Pillet B, Puissant A. Pachydermoperiostosis With Gastric Hypertrophy, Anemia, and Increased Serum Bone Gla-Protein Levels. Arch Dermatol. 1988;124(12):1831-1834. doi:10.1001/archderm.1988.01670120047009