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January 1989

Penicillamine Dermatopathy With LymphangiectasesA Clinical, Immunohistologic, and Ultrastructural Study

Author Affiliations

From the Departments of Medicine (Dermatology) (Drs Goldstein, McNutt, and Hambrick), Pathology (Dr McNutt and Ms Hsu), New York Hospital-Cornell University Medical College, New York.

Arch Dermatol. 1989;125(1):92-97. doi:10.1001/archderm.1989.01670130094014

• The term penicillamine dermatopathy refers to the characteristic hemorrhagic skin lesions found in persons receiving long-term penicillamine therapy for either Wilson's disease or cystinuria. These lesions are thought to develop as a result of faulty collagen and elastin synthesis. We describe a patient with Wilson's disease who developed extensive penicillamine dermatopathy. In addition, histologic, immunochemical, and ultrastructural studies revealed multiple lymphangiectases with blood vessel to lymphatic anastomosis within these lesions, a finding not previously reported. The possible relationship to defective collagen and elastin formation are considered.

(Arch Dermatol 1989;125:92-97)