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March 1989

Prevalence and Clinical Spectrum of Skin Disease in Patients Infected With Human Immunodeficiency Virus

Author Affiliations

From the Department of Dermatology, University of Texas Southwestern Medical Center, Dallas. Dr Coldiron is now with the Department of Dermatology, University of Illinois at Chicago.

Arch Dermatol. 1989;125(3):357-361. doi:10.1001/archderm.1989.01670150047004

• We examined 100 serial patients who were receiving care in a county outpatient immunodeficiency clinic and whose serum was positive by Western blot test for the human immunodeficiency virus (HIV). Skin disorders were found in 92% of these HIV-infected patients, with little difference in prevalence or severity in three clinical categories: patients with the acquired immunodeficiency syndrome, patients with acquired immunodeficiency syndrome—related complex, and those who were asymptomatic. Patients positive for HIV antibodies had significantly more skin disease, with the exception of dermatophytosis, than did a historical control population. A strong association was observed between the use of zidovudine and the absence of infection with Candida albicans. We conclude that there is a high prevalence of skin disease in HIV-positive patients who seek medical care, and that specialists in skin disease should be included in these patients' initial evaluation and continuing care.

(Arch Dermatol 1989;125:357-361)