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April 1989

Malignant Melanoma: Biology, Diagnosis, and Therapy

Author Affiliations

Providence, RI

Arch Dermatol. 1989;125(4):578. doi:10.1001/archderm.1989.01670160126039

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Malignant melanoma is of interest to researchers for many reasons. It is the leading cause of death among dermatologic disorders; it is increasing rapidly in incidence; tissue is relatively easy to obtain for study in the laboratory at both early and late stages; and it appears to be particularly responsive to immunologic factors. The intense interest in melanoma includes many disciplines and many lines of investigation. This book reports on 11 of the many foci of melanoma research.

Four of these involve reviews of laboratory investigations of the biology of this tumor. Rodeck and Herlyn provide a brief overview of the antigens and growth characteristics of nevomelanocytes and melanoma in culture. Ravindranath and Irie discuss ganglioside melanoma antigens in greater detail. They mention some recently published results regarding the therapeutic use of these antigens, and of monoclonal antibodies to them, in human melanoma. Parmiter and Nowell follow with a review

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