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Article
July 1989

Mediators of Inflammation in Blister Fluids From Patients With Pemphigus Vulgaris and Bullous Pemphigoid

Author Affiliations

From the Unit of Immunodermatology (Dr Grando) and Chair of Dermato-Venereology (Drs Grando and Glukhenky and Mr Korostash), Kiev (USSR) State Advanced Training Institute for Doctors; Centre for Clinical and Experimental Immunology, UkrSSR Academy of Sciences and Ministry of Health, Kiev (Dr Drannik); Radioimmunology Laboratory, Kiev, Institute of Endocrinology (Dr Epshtein); and Laboratory of Immunobiology, Kiev State University (Dr Kostromin).

Arch Dermatol. 1989;125(7):925-930. doi:10.1001/archderm.1989.01670190059006
Abstract

• Blister fluids from 39 previously untreated patients with pemphigus vulgaris (PV) and 28 patients with bullous pemphigoid (BP) were tested for the presence of inflammatory mediators. Blister fluids from patients with PV and BP showed interleukin 1 (IL-1)- and interleukin 2 (IL-2)-like activity and contained prostaglandin (PG) E2, F, and F, thromboxane B2 (TB2), leukotriene (LT) B4 and C4, serine esterases, and proteolysis inhibitors. Pemphigus blister fluid was distinguished by high IL-1-like activity, proteolytic activity, and high concentrations of TB2 and LTB4, while pemphigoid blister fluid was characterized by higher IL-2-like activity, antiprotease activity, and high PGE2 concentration. We also determined that the content of mediators of inflammation varied depending on the duration of blister development. In both PV and BP, the initially high IL-1-like activity, amount of serine proteases, and concentrations of PGF, TB,2 LTB4, and LTC4 decreased by the fifth day of blister existence, whereas antiprotease activity as well as PGE2 and PGF concentrations gradually increased as blisters developed. These findings suggest certain differences in the character of the bullous inflammatory process in pemphigus and pemphigoid.

(Arch Dermatol 1989;125:925-930)

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