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September 1989

Dyslipoproteinemia in Patients With Xanthelasma-Reply

Author Affiliations

Hospital Sant Pau Barcelona, Spain

Arch Dermatol. 1989;125(9):1282. doi:10.1001/archderm.1989.01670210120024

In Reply.—  In any study about xanthelasmas, patient selection is of utmost importance. Pintó and coworkers do not explain the origin of their patients, and some of the differences encountered in their study could be due to a different selected population.Further data not included in our article revealed that, among first-degree relatives of our 50 patients with xanthelasma, only two had cardiovascular disease.We did compare our patients with xanthelasmas with a normal control population chosen so that the controls contained approximately equal numbers of subjects of the same age, sex, and weight. The group of patients with xanthelasmas (40% of them hyperlipemic) showed higher levels of cholesterol, triglycerides, very-low-density cholesterol, and low-density lipoprotein cholesterol than the control group. However, the levels of apoprotein B were equal, and the levels of phospholipids were higher when we compared the group of xanthelasmas with a nonselected population (Table).1 The hyperlipemic phenotypes among the two groups were almost similar, and the hyperlipemia

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