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October 1989

Persistent Vesicular Eruption in an Infant

Author Affiliations

University of Maryland School of Medicine, Baltimore

Arch Dermatol. 1989;125(10):1419-1420. doi:10.1001/archderm.1989.01670220115021

REPORT OF A CASE  A 19-month-old previously healthy girl presented with a 1-week history of a blistering eruption in her diaper area. She was treated for bullous impetigo with a 10-day course of oral erythromycin therapy. The eruption persisted and the antibiotic therapy was changed to dicloxacillin sodium. There was no significant family history.Physical examination demonstrated many discrete, tense vesicles on normal-appearing skin in the diaper area, extending to the anterior trunk and extremities (Fig 1). The vesicles often formed annular configurations. Postinflammatory hyperpigmentation was prominent in the groin; there was no milia or scarring.The following test results were normal: complete blood cell count, liver and renal function tests, and glucose-6-phosphate dehydrogenase. Staphylococcus aureus sensitive to erythromycin and dicloxacillin was isolated from bacterial culture. Herpes group cultures were negative.Because new lesions continued to develop, twicedaily application of 0.05% fluocinonide cream was begun and a skin biopsy specimen

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