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November 1989

Short-term Cyclosporine Therapy for Psoriasis-Reply

Author Affiliations

Department of Dermatology University of Michigan Medical Center Ann Arbor, MI 48109-0314

Arch Dermatol. 1989;125(11):1582-1583. doi:10.1001/archderm.1989.01670230124026

In Reply.—  We would like to thank Harrison for his comments regarding our recent article. We have also noticed that psoriasis usually relapses on discontinuation of cyclosporine.1,2 This drug, at least following short-term therapy (up to 12 weeks), does not normally induce long-term remissions in patients with severe psoriasis.1,2 In our experience, when the psoriasis recurs, the disease usually worsens to an extent similar to that of pretherapy; the rate of recurrence appears to be related to the stability of the patient's psoriasis before initiating cyclosporine (that is, patients with active and inflammatory psoriasis tend to have relapses faster than those who normally have stable plaque disease).We cannot advocate long-term administration of cyclosporine until more information about its safety can be determined. Indeed, we are currently involved in a substantial trial of long-term therapy in psoriasis in order to answer this question. In the meantime, prolonged administration of

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