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November 1989

Human Papillomavirus Associated With Keratoacanthoma

Author Affiliations

Department of Dermatology The University of Texas Medical School 6431 Fannin, MSB 1.204 Houston, TX 77030

Department of Microbiology The University of Texas Dental Branch Houston, TX 77030

Arch Dermatol. 1989;125(11):1587-1589. doi:10.1001/archderm.1989.01670230129031

To the Editor.—  At least 58 types of human papillomaviruses (HPVs) have been identified to date, and they are associated with a variety of cutaneous diseases. Human papillomavirus has long been known to cause common warts and condylomata accuminata, and certain HPV types have been linked to bowenoid papulosis, genital Bowen's disease, genital squamous cell carcinoma, and epidermodysplasia verruciformis. More recently, there has been some association of HPV with nongenital Bowen's disease and nongenital squamous cell carcinoma. There have been isolated reports of the detection of HPV DNA in basal cell carcinoma, malignant melanoma, solar keratosis, and hairy leukoplakia, but the significance of these findings is uncertain. Several European reports have described the detection of HPV in keratoacanthoma (KA),1-3 but, to our knowledge, there have been no reports from the United States until now. We report the detection of HPV in eight keratoacanthomas using DNA hybridization techniques.

Materials and 

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