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December 1989

Improvement of Palmoplantar Keratoderma of Nonhereditary Type (Eczema Tyloticum) After Oral Administration of 1a,25-Dihydroxyvitamin D3

Author Affiliations

Department of Dermatology Jichi Medical School Minamikawachi-machi Kawachi-gun Tochigi-ken 329-04, Japan

Arch Dermatol. 1989;125(12):1713. doi:10.1001/archderm.1989.01670240115030

To the Editor.—  Eczema tyloticum, a nonhereditary type of palmoplantar keratoderma, is an incurable disease. We recently found the remarkable therapeutic effect of 1α,25-dihydroxyvitamin D3 on this disease.

Report of a Case.—  A 58-year-old man presented to our hospital in April 1987 with hyperkeratosis and cracking of the skin on the palms of his hands and the soles of his feet that developed over a 1-year period, with no specific cause. There was no family history of such a disease, nor was there any noteworthy history.On physical examination, hyperkeratosis was localized on the palms of his hands and the soles of his feet. Lesions of tylosislike hyperkeratosis with a yellowish appearance, ranging in size from soybean to chicken egg, were spread over the soles of his feet except for the plantar arch. There were many hyperkeratotic lesions

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