To the Editor.—
Hidrotic ectodermal dysplasia (HED) is an uncommon autosomal-dominant disorder characterized by palmoplantar hyperkeratosis, dystrophy of the nails, and defects of the hair. It is sometimes associated with a large constellation of other abnormalities.1 In this report, we describe a case of HED in a patient with numerous papules on the palmoplantar surfaces, which revealed the histologic pattern of the eccrine syringofibroadenoma.
Report of a Case.—
A 53-year-old woman presented in our clinic with a thickening of palms and soles, hypotrichosis, and defects of the nails that had been present since infancy. For at least 2 years she had noticed papular lesions on the soles and palms. She was the fourth of five siblings of nonconsanguineous parents. Only her elder brother, 63 years of age, exhibited a similar condition, but he refused to undergo the skin biopsies. She told us that her teeth were conical, small, and
Aloi FG, Torre C. Hidrotic Ectodermal Dysplasia With Diffuse Eccrine Syringofibroadenomatosis. Arch Dermatol. 1989;125(12):1715. doi:10.1001/archderm.1989.01670240117032