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February 1990


Author Affiliations

Department of Dermatology Dennis P. West, MS, FCCP Departments of Pharmacy Practice & Dermatology University of Illinois 808 S Wood St Chicago, IL 60612

Department of Medicinal Chemistry and Pharmacognosy University of Illinois 833 S Wood St Chicago, IL 60612

Arch Dermatol. 1990;126(2):248. doi:10.1001/archderm.1990.01670260120030

To the Editor.—  Further on the use of lindane as a pediculicide in humans. The letters of December 1988, from McIlreath and from Reed and Carnrick of Kwell fame, has convinced us that lindane in concentrations lower than the commercially available product is ineffective as a pediculicide. This adds to the increasing need to do away with this drug for the treatment of lice in humans.Lindane has long been known as a neurotoxin, which is also the basis of its effectiveness. Over the last 10 years, however, the mechanism by which this occurs has become understood. Lindane blocks the chloride ion channel by antagonizing γ-aminobutyric acid stimulation of chloride ion uptake through the channel complex of the benzodiazepine receptor. Its specificity for this activity is shown by the inactivity of the other isomers of lindane.1-3Kindling is a well accepted method for screening epileptogenic or convulsive compounds and

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