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March 1990

Cyclosporine Therapy for Bullous Erythema Multiforme

Author Affiliations

Division of Dermatology Brown University and Roger Williams General Hospital 825 Chalkstone Ave Providence, RI 02908

Arch Dermatol. 1990;126(3):397-398. doi:10.1001/archderm.1990.01670270129025

To the Editor.—  Immunosuppressive therapy with cyclosporine introduced in the 1970s dramatically improved the survival of kidney, liver, and heart transplants. The reported use of cyclosporine for treatment of dermatological disease is increasing in frequency, and favorable responses have been observed in the treatment of psoriasis, Behçet's disease, bullous pemphigoid, pemphigus vulgaris, dermatomyositis, polymyositis, ichthyosis, and several other cutaneous disorders.1 We report on the successful treatment of a patient with severe bullous erythema multiforme that had previously responded only partially to high dosages of systemic corticosteroids.

Report of a Case.—  A 23-year-old white woman was referred to our dermatology service in August 1987 for evaluation of a bullous eruption of 3 years' duration. The patient was in good health until 1984 when, approximately 1 week after a dental procedure, she developed a generalized eruption and oral ulcerations. The initial eruption cleared after an intramuscular dose of penicillin. Four

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