• Cutaneous melanoma developed in contiguity with a congenital nevus spilus on the leg of a 79-year-old white woman. The unique features of the nevus spilus in this case were its relatively large size (diameter, 8 cm), irregular gross appearance, lifelong stability until the recent appearance of a tumor nodule, and the presence of intraepidermal melanocytic dysplasia appearing as multifocal elements within darkly pigmented speckles distributed throughout a lightly pigmented background of lentigo simplex. Based on this observation, we suggest that the presence of intraepidermal melanocytic dysplasia in nevus spilus may be a predisposing factor for the development of melanoma. The malignant potential of "dysplastic" nevus spilus requires further study.
(Arch Dermatol. 1990;126:500-505)
Rhodes AR, Mihm MC. Origin of Cutaneous Melanoma in a Congenital Dysplastic Nevus Spilus. Arch Dermatol. 1990;126(4):500-505. doi:10.1001/archderm.1990.01670280084015