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May 1990

Polymyositis in Association With Melanoma

Author Affiliations

The Sydney Melanoma Unit Department of Surgery University of Sydney Royal Prince Alfred Hospital Missenden Road Camperdown, New South Wales 2050, Australia

Arch Dermatol. 1990;126(5):686-687. doi:10.1001/archderm.1990.01670290134031

To the Editor.—  Melanoma (MM) in association with polymyositis (PM) has been documented in just one previous case report,1 while dermatomyositis (DM) has been reported relatively more frequently.2-4 We describe the only case of PM associated with MM in the series of 8400 patients of the Sydney (Australia) Melanoma Unit.

Report of a Case.—  In early 1982, a 58-year-old man noted onset of shoulder pain followed by general weakness, and in February 1983, his creatine phosphokinase concentration rose to 1700 U/L. Electromyograms showed myopathic changes and analysis of a left deltoid muscle biopsy specimen confirmed diagnosis of PM (Figure).His disease was well controlled by oral prednisone 50 mg/d until he experienced a temporary exacerbation several months later due to a retained renal stone. Subsequent to nephrolithotomy, the creatine phosphokinase level and muscle strength returned to normal. He remained well until August 1984 when his creatine phosphokinase level