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August 1990

Multiple Cutaneous Granular Cell Tumors and Neurofibromatosis in ChildhoodA Case Report and Review of the Literature

Author Affiliations

From the Departments of Dermatology (Drs Martin, Neldner, and Boyd) and Cell Biology and Anatomy (Dr Coates), School of Medicine, Texas Tech University Health Sciences Center, Lubbock.

Arch Dermatol. 1990;126(8):1051-1056. doi:10.1001/archderm.1990.01670320075013

• Multiple cutaneous granular cell tumors have been previously reported in only 26 children or adolescents. An association of these tumors with neurofibromatosis has never been reported previously. We describe a 12-year-old black girl with multiple cutaneous granular cell tumors and neurofibromatosis. Although the histogenesis of these tumors is not completely clear, the findings of ultrastructural and immunohistochemical evaluation of our patient's tumors and the associated neurofibromatosis support a neural crest origin for granular cell tumors.

(Arch Dermatol. 1990;126:1051-1056)