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August 1990

Characterization of Cellular Elements in Healed Cultured Keratinocyte Autografts Used to Cover Burn Wounds-Reply

Author Affiliations

Division of Dermatology University of Utah School of Medicine Salt Lake City, UT 84132

Department of Dermatology Stanford University School of Medicine Stanford, CA 94305

Arch Dermatol. 1990;126(8):1105. doi:10.1001/archderm.1990.01670320129030

In Reply.—  We appreciate the comments by Phillips, Bhawan, and Gilchrest, and are pleased that they have found a similar suprabasilar AE1 staining pattern in their allografts.1 The fact that the AE1 staining later reverted to a normal pattern in their biopsy specimens and did not in our autografts observed as long as 23 weeks after transplantation, may reflect the differences in the wound bed onto which the grafts were placed. It may well be that grafts placed on muscle fascia (as in our patients), instead of dermis, retain the hyperproliferative phenotype longer, or, possibly, indefinitely.It is difficult to extrapolate the findings of Mansbridge and Knapp2 in suction blister wounds and tape-stripped skin since these very superficial wounds cannot be compared with split- and full-thickness dermal wounds that are much deeper. We agree that the reversal of the normal AE1 staining pattern likely represents an injury response that

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