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September 1990

Treatment of Actinic Prurigo With Intermittent Short-Course Topical 0.05% Clobetasol 17-PropionateA Preliminary Report

Author Affiliations

From the Division of Dermatology, Department of Medicine, University Hospital, University of Saskatchewan, Saskatoon, Canada.

Arch Dermatol. 1990;126(9):1211-1213. doi:10.1001/archderm.1990.01670330091014

• Actinic prurigo is a chronic familial photodermatosis that occurs mostly in Amerindians. Eight patients with actinic prurigo were given intermittent 3- to 14-day courses of topical 0.05% clobetasol 17-propionate cream or ointment in 1988 and 1989. Seven out of eight patients cleared or markedly improved. All of the patients had been resistant previously to milder topical corticosteroids. There have been no side effects. This therapy offers an effective alternative to systemic corticosteroids, oral psoralen with long-wave UV radiation in the A range, or thalidomide.

(Arch Dermatol. 1990;126:1211-1213)