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September 1990

Chronic Urticaria Associated With Exogenous Thyroid Use

Author Affiliations

Department of Dermatology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75235-9069

Department of Dermatology University of Pittsburgh School of Medicine 3601 Fifth Ave Pittsburgh, PA 15213

Arch Dermatol. 1990;126(9):1238-1239. doi:10.1001/archderm.1990.01670330118025

To the Editor.—  Chronic urticaria and angioedema are relatively common and are difficult clinical problems in dermatology. Recently, we evaluated a patient with chronic urticaria and angioedema that was associated with oral thyroid replacement.

Report of a Case.—  A 53-year-old white woman presented with a 6-month history of urticaria, angioedema, and pruritus. Salicylatefree diets, rotation diets, as well as immunotherapy for environmental antigens had all failed to help. Continual use of antihistamines supplemented with intermittent short courses of oral corticosteroids would control, but not alleviate, her symptoms. In the interim, she had disconnected her air conditioner, changed bedrooms, discontinued her shampoo and soap, and had lost weight from her rotation diet.The patient had received thyroid tablets (Armour), three grains daily, as replacement therapy since her thyroidectomy 20 years previously for thyrotoxicosis. Thyroid function tests had not been performed for 6 years. At the initial visit, she complained of fatigue,

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