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September 1990

Eruptive Nevi in Addison's Disease

Author Affiliations

Department of Dermatology

Department of Pathology Odense University Hospital DK-5000 Odense C, Denmark

Arch Dermatol. 1990;126(9):1239-1240. doi:10.1001/archderm.1990.01670330119026

To the Editor. —  Pigmented nevi may be present at birth, but commonly appear later. Excessive numbers of nevi may be a family trait. They may appear in crops at puberty, during pregnancy, and following corticotropin administration1. In Addison's disease pigmentation is usually diffuse, but most intense in light-exposed areas and in the creases of the palms and soles. Pigmentation of the buccal mucosa is almost pathognomonic of "endocrine melanosis." The hyperpigmentation is secondary to increased secretion of melanotropic hormones (eg, melanocyte stimulating hormone [MSH]) by the pituitary gland.We report a case of eruptive nevi associated with Addison's disease.

Report of a Case.—  A 41-year-old man was admitted in June 1989 because of fatigue, vomiting, abdominal pains, and a weight loss of 12 to 14 kg during the previous 3 to 4 months. He had noticed the development of numerous dark-brown macules on the body and extremities during

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