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September 1990

Adult-Onset Leukoderma and Malignant Melanoma

Author Affiliations

Department of Dermatology University of Arkansas for Medical Sciences 4301 W Markham, Slot 576 Little Rock, AR 72205

Arch Dermatol. 1990;126(9):1240-1241. doi:10.1001/archderm.1990.01670330120027

To the Editor.—  Adult-onset leukoderma was attributed to a visceral malignancy; however, 1 year later an acral lentiginous melanoma was noted.

Report of a Case.—  A 68-year-old black man presented to the John L. McClellan Veterans Administration Hospital, Little Rock, Ark, during July 1988. At that time he was evaluated by the otolaryngology service for hoarseness of 2 months' duration. A diagnosis of squamous cell carcinoma of the larynx, stage T3, NO, MO, was made that would require a total laryngectomy and subsequent radiation.Prior to surgery, the dermatology service was consulted because of patchy pigmentary loss that the patient had developed over the 2 months prior to hospital admission. Cutaneous examination showed widespread hypopigmented and depigmented macules and patches, mostly above the waist (Fig 1). His soles were not inspected. The simultaneous occurrence of hoarseness and the striking widespread leukoderma was felt to be more than coincidental, and the

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