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October 1990

Abnormal Essential Fatty Acid Metabolism in Darier's Disease

Author Affiliations

From the Departments of Dermatology (Dr A. Oxholm) and Dentistry (Dr P. Oxholm), University of California, San Francisco; the Department of Dermatology, Bispebjerg (Denmark) Hospital (Dr da Cunha Bang); and the Efamol Research Institute, Kentville, Canada (Dr Horrobin). Dr A. Oxholm is now with the Department of Dermatology; Bispebjerg (Denmark) Hospital.

Arch Dermatol. 1990;126(10):1308-1311. doi:10.1001/archderm.1990.01670340060008

• Fatty acid levels in plasma and erythrocyte cell membranes were determined in 13 Danish patients with Darier's disease and 21 Danish controls. Concentrations of the main dietary essential fatty acids, linoleic acid (18:2n-6) and α-linolenic acid (18:3n-3), were consistently modestly above normal; concentrations of the Δ6-desaturase metabolites of both linoleic and α-linolenic acids, however, were consistently and often significantly below normal. These results suggest that the capacity of the enzyme Δ6-desaturase activity is inadequate in patients with Darier's disease.

(Arch Dermatol. 1990;126:1308-1311)