• Reports of pemphigus following ionizing radiation exposure are rare. We report two cases and review the literature regarding this association. Characteristics common to these cases include a prodromal persistent non-specific dermatitic eruption that is often interpreted as radiation dermatitis, and latency of variable duration before the onset of a vesiculobullous eruption that begins at the portal of irradiation. Direct immunofluorescence is positive for intercellular IgG, while indirect immunofluorescence is commonly positive only at low titers; HLA correlations have not been studied. Documentation of clinical course and laboratory confirmation of the diagnosis, including hematoxylin-eosin, direct and indirect immunofluorescence, and HLA determinations (if available), should be recorded to enable further clarification of this entity.
(Arch Dermatol. 1990;126:1319-1323)
Low GJ, Keeling JH. Ionizing Radiation-Induced PemphigusCase Presentations and Literature Review. Arch Dermatol. 1990;126(10):1319-1323. doi:10.1001/archderm.1990.01670340071011